The bacterial pathogen, Salmonella enterica, colonizes a variety of different cell types in an infected mammalian host. It has long been accepted that Salmonella reside within a membrane-bound vacuole within these cells. However, I recently described a subpopulation of bacteria that are free within the cytosol of epithelial cells. These bacteria are rapidly replicating, express a distinct set of virulence genes compared to vacuolar bacteria, and induce an inflammatory form of host cell death known as pyroptosis. I will discuss my recent findings about this unexpected intracellular lifestyle of Salmonella.
Link to video.