Date:
Wednesday, April 4, 2012
Speaker:
Leigh A. Knodler, Ph.D., Staff Scientist, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH
Time and location:
4:00PM - Room 150 - EPI Research Facility or view from your desktop: http://seminar.epi.ufl.edu The bacterial pathogen, Salmonella enterica, colonizes a variety of different cell types in an infected mammalian host. It has long been accepted that Salmonella reside within a membrane-bound vacuole within these cells. However, I recently described a subpopulation of bacteria that are free within the cytosol of epithelial cells. These bacteria are rapidly replicating, express a distinct set of virulence genes compared to vacuolar bacteria, and induce an inflammatory form of host cell death known as pyroptosis. I will discuss my recent findings about this unexpected intracellular lifestyle of Salmonella.
Link to video.