Date:
Tuesday, January 11, 2011
Speaker:
Dr. George Drusano, M.D., Co-Director, Ordway Research Institute / Professor and Director, Division of Clinical Pharmacology, Departments of Medicine & Pharmacology, Albany Medical College
Time and location:
4:00 PM - EPI Seminar Room 150 or view from your desktop: http://seminar.epi.ufl.edu/ There are several beta lactam agents with potent activity against Pseudomonas aeruginosa. While several can attain a resistance-suppression target in the blood, few, if any can attain such a target for an acceptable fraction of patients at the infection site where a dense population of organisms exists, such as in a patient with Ventilator-Associated-Pneumonia (VAP). Combination chemotherapy allows additive to synergistic interaction for bacterial cell kill in most instances and suppresses amplification of resistant subpopulations. Multi-resistant Pseudomonas and Acinetobacter spp are an area where the extra toxicity and expense of combination agent therapy may be worth it.
LINK to video