The delta family of ionotropic glutamate receptors (iGluRs) consists of glutamate delta-1 (GluD1) and glutamate delta-2 (GluD2) receptors. The function of GluD1 in the central nervous system (CNS) remains elusive. The GRID1 gene that codes for GluD1 has been implicated in neuropsychiatric disorders. Using electrophysiological and behavioral assays we have studied the structure and functional significance of the GluD1 receptor. Our data characterizes the ion channel function of the GluD1 receptor. We hypothesize that synaptic abnormalities due to GluD1 deletion would lead to aberrant behaviors. We have found aberrant behavioral phenotypes and molecular abnormalities in GluD1 knockout mice. These data suggest GluD1 functions in regulation of behavior and synaptic physiology.
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